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Skin Biohacking: Smarter Skin Solutions

The Three Pillars of Skin Optimisation

Today’s skincare consumer isn’t just chasing hydration; they’re demanding innovation. From performance-boosting actives to longevity-supporting compounds, skin biohacking is redefining what it means to care for your skin. It’s about working with the skin’s biology to enhance function, resilience, and radiance.

Ready to take your formulations to the next level? Here are the must-have ingredients to help you tap into the skin biohacking movement.

1. Cellular Communication: The Signal Boosters

These ingredients work like smart messengers by communicating directly with skin cells to repair, regenerate, and activate the production of essential components at optimal levels.

ALTHEOSTEM™ from Provital

Powered by cutting-edge biotech, this lab-grown active, derived from the petal stem cells of Althaea rosea (yes, it’s as elegant as it sounds), is more than just a pretty face. It’s a dermohacking dynamo, sending a clear signal to the skin: out with the old, in with the youthful.

This multi-award-winning senolytic targets and clears out senescent fibroblasts, the "noisy" cells that disrupt the skin’s natural rhythm. By restoring clarity to the dermal network, it paves the way for fresher, firmer, healthier skin formulations.

Think of it as biotech beauty with brains, a smart, skin-savvy solution that speaks the skin’s language and keeps it glowing.

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Vegan DDS Pure Retinal from INdermal

Vegan DDS Pure Retinal gets to work like a skincare superhero, boosting the skin’s natural production of hyaluronic acid, collagen, and elastin to keep it firm, bouncy, and strong. It speeds up skin cell renewal for a fresher, smoother look, helping to refine texture, minimise pores, and leaves complexion glowing with confidence.

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GAÏALINE® from Laboratoires Expanscience

Created through high-tech molecular distillation, this powerhouse ingredient delivers a concentrated dose of rare goodies (aka unsaponifiables) from linseed oil. It works wonders to protect, strengthen, and rebuild the skin barrier, helping to slow down the signs of ageing. Clinically proven, GAÏALINE® gets deep into the skin to revive and energise, giving that fresh “new skin” glow from the inside out.

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Vegan DDS EGF

INCI: Aqua, Mannitol, Phosphatidylcholine, Glycerin, Cetyl Alcohol, Decyl Glucoside, Potassium Sorbate, Sodium Benzoate, Xanthan Gum, Sodium Chloride, Dipotassium Phosphate, Oligopeptide-1, Potassium Phosphate

Deep Delivery Nanovesicles with Epidemic Growth Factor (EGF)

Exo DDS Bakuchiol

INCI: Aqua, Polyglyceryl-10 Laurate, Glycerin, Propanediol, Phosphatidyylcholine, Bakuchiol, Cocobetaine, Persea Gratissima Fruit Extract, Butyl Avocadete, Maltodextrin, Sodium Cocoyl Isethionate, Caprylyl Glycol, Betasitosterol, Citric Acid, Phenylpropanol, Cocos Nucifera Oil, Sodium Isethionate, Tocopherol

Deep Delivery Nanovesicles with 1% Bakuchiol + Avocado Exosome

BLUE ALGA

INCI: Cystoseira tamariscifolia extract, Triheptanoin

Oil-soluble, neuro-active algae extract designed to enhance skin protection, strengthen the skin and promote a more resilient and glowing complexion.

2. Built to Glow: The Base Builders

Skin optimisation begins at the base, with a strong, balanced foundation. These powerhouse ingredients work to fortify the skin’s barrier and support a thriving microbiome, helping skin stay resilient, healthy, and ready to perform at its best.

CERAFLUID from ROELMI

This hardworking hydrator is all about building a solid foundation for happy, healthy skin.

It delivers long-lasting hydration while helping skin cells stick together better, strengthening the barrier so moisture stays in and pesky aggressors stay out. Creating a smoother, bouncier, more elasticated skin that’s protected, plump, and perfectly prepped for anything layered on top. Say goodbye to dehydration and hello to the skin’s new comfort zone!

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DefensoWin™ from ROELMI

This skin-loving probiotic is like a personal trainer for the skin’s microenvironment, keeping things balanced, calm, and ready to take on the day. It helps protect against environmental stress while delivering deep, lasting hydration. It also strengthens the skin barrier, so the complexion stays smooth, resilient, and beautifully balanced.

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Pixalia® from Laboratoires Expanscience

This clever botanical extract, packed with polyphenols and sourced from the dried leaves of Cleome gynandra, is the skin’s secret weapon for balance and clarity. It helps rebalance the skin’s microbiota, keeps C. acnes in check, and regulates sebum, not just production but the quality too. By targeting oxidative squalene, it helps keep skin fresh, clear, and comfortable.

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PUREBLOME™

INCI: Aqua, Propanediol, Glycerin, Bacillus Ferment, Pentylene Glycol, Levulinic Acid, Glyceryl Caprylate

A triple-efficacy active that improves female adult-acne, oily skin and inflammation while preventing ageing signs.

PrincipHYAL® Aurora

INCI: Sodium Hyaluronate

Skin regeneration, repair and cell proliferation active.

PrincipHYAL® Difference

INCI: Sodium Hyaluronate

Long term anti-ageing active based on second generation Hyaluronic acid technology.

PrincipHYAL® Signal-10

INCI: Hyaluronic Acid

Fast track moisturising and skin regeneration active derived from ultra-low mwt. Hyaluronic Acid.

PrincipHYAL® Cube3

INCI: Sodium Hyaluronate

Instant lifting and tightening active based on next generation Hyaluronic Acid technology.

3. Longevity & Energy: The Inner Defence

Fueling the skin from within starts at the cellular level. By targeting the mitochondria, the cells’ energy hubs and enhancing their defense systems, these ingredients help power long-term skin vitality, strength, and resilience.

BOREALG TG from ODYCEA

Sourced from the wild, wave-crashing seaweed (Laminaria hyperborea), this resilient sea plant is a true survivor, thriving through winter storms and powerful ocean swells. Thanks to its incredible natural repair system, it brings those same regenerative powers to the skin.

A dream ingredient for building strong, healthy skin, it helps kickstart the skin’s renewal process and calms redness by working in harmony with the skin’s biology. By targeting everything from mitochondrial energy to Leptin receptors and key skin proteins like FABP3 and Cyclin D1. Creating smoother, calmer, more radiant skin.

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DETOSKIN™ from Provital

This smart longevity-boosting ingredient gives your skin’s mitochondria a much-needed refresh by activating mitophagy, think of it as a cellular spring clean. By clearing out damaged components and recharging energy levels, skin cells regain their vitality and function more youthfully over time. Resulting in fewer wrinkles, smoother texture, and a more even tone that lasts.

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Ener-GY plus from ROELMI

This high-performing ingredient is all about long-term skin vitality. Powered by advanced enzymatic technology and delivered in a sustainable, upcycled Mediterranean fruit matrix, it supports skin longevity from within. The star player, glyceryl glucoside, energises tired cells by activating key mitochondrial pathways and boosting ATP production, fueling healthy and resilient skin.

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Vegan DDS Niacinamide

INCI: Aqua, Mannitol, Phosphatidylcholine, Glycerin, Niacinamide, Cetyl Alcohol, Potassium Benzoate, Sodium Benzoate, Xanthan Gum, Citric Acid, Sodium Chloride

Encapsulated Niacinamide for healthy looking skin

Ayuredi®

INCI: Propanediol, Water, Ocimum Sanctum Leaf Extract

Protect the skin from environmental and psychological stresses, in particular damages linked to cortisol

ENERGEN™

INCI: Glycerin, Aqua, Sapindus Mukorossi Fruit Extract, Caesalpinia Spinosa Gum,Potassium Sorbate, Sodium Benzoate

Source of energy for men's skin. Increases cellular ATP. Tonifying. Reduces relief imperfections. Moisturising. Revitalising. Prolonged-delivery technology exclusive of Provital, 3D Matrix.

Formulation Inspiration

Ready to formulate the future? Take a look at our partner formulation inspirations below.

  • Skin Reviving Antidote
  • Defense and Lipid Replacement Cream
  • Energy Boosting Potion
  • Anagennesis Skin & HairRegen' Jelly Mask
  • Pearl Serum

Summary

Skin biohacking is the next-gen approach to skincare, where science meets smart formulation to supercharge skin from the inside out.

By tapping into our must-have ingredients that energise cells, optimise barrier function, and balance the skin’s microbiome, you can create products that do more than just moisturise - they train the skin to be healthier, stronger, and more resilient over time.

Related Article: Solutions by Skin Type

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